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ABSTRACT
We reported the case of a patient with Wernicke-Korsakoff syndrome (WKs) as an early clinical manifestation of sporadic Creutzfeld-Jakob disease (sCJD). The 66-year-old female complained of dizziness and imbalance which mostly occurred while walking. A neurological examination revealed a triad of symptoms characteristic for WKs such as gaze paresis, ataxia of limbs and trunk as well as memory disturbances with confabulations. The disturbances increased during the course of the disease, which led to the death of the patient four months after the appearance of the signs. The patient was finally diagnosed with sCJD disease. The most useful ancillary examination results supporting sCJD diagnosis were brain diffusion DWI MRI (diffusion weighted magnetic resonance imaging) and the presence of 14–3-3 protein in CSF (cerebrospinal fluid). Since that manifestation of sCJD is very unique other causes should be taken into consideration while making a final diagnosis.
Abbreviations
| WKs | = | Wernicke-Korsakoff syndrome |
| sCJD | = | sporadic Creutzfeld-Jakob disease |
| MRI | = | magnetic resonance imaging |
| DWI | = | diffusion weighted imaging |
| CT | = | Computed Tomography |
| CSF | = | cerebrospinal fluid |
| EEG | = | electroencephalogram |
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.