Maternal smoking as a risk factor for childhood intussusception

ABSTRACT

Risk factors for intussusception have only rarely been reported. We examined the association between the risk of hospital admission for intussusception and maternal smoking, using a nationwide population-based longitudinal survey begun in Japan in 2010. Maternal smoking status was queried at 6 months of age, and responses to questions at 18 months of age about history of hospitalization for intussusception during the previous year were used as an outcome of interest. We conducted logistic regression analyses controlling for potential confounding factors. Maternal smoking increased the risk of hospitalization for intussusception (adjusted OR = 2.75, 95% CI [1.09, 6.96]) compared with not smoking, and a dose-response relationship was observed for the association. Maternal smoking is associated with an increased risk of intussusception development in children between the ages of 6 and 18 months.

KEYWORDS:

• Children
• epidemiology
• intussusception
• maternal smoking

Acknowledgment

The authors thank Saori Irie for her help in preparing the article.

Ethics

This study was approved by the Institutional Review Board at Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences (no.1506-073).

Additional information

Funding

This study is partly supported by Grant for Strategies for Efficient Operation of the University (2007030201).