Antidiabetic Activity of Triticum aestivum Seed–Based Diet on Alloxan-Induced Diabetic Rats

Abstract

The antidiabetic activity of Triticum aestivum seed–based diet on alloxan-induced diabetic rats was investigated. Forty-eight male and female albino rats of four groups were used for this study. Rats were sacrificed on day 28 and organs of interest were excised. Triticum aestivum seed–based diet significantly (p < .05) reversed the levels of fasting blood glucose, albumin, globulin, bilirubin, urea, creatinine, Na⁺, and K⁺. In addition, diabetic rats fed Triticum aestivum seed–based diet had significantly (p < .05) increased insulin and glycogen concentrations, activities of hexokinase, catalase, superoxide dismutase, and glutathione peroxidase and the levels of hematological parameters studied. Diabetic rats fed on Triticum aestivum seed had significantly (p < .05) reduced activities of glucose-6-phosphatase and fructose 1,6-diphosphatase and concentration of MDA and reversed activities of AST and GGT; ALP and regeneration of liver, kidney, and pancreas tissues compared favorably with the control group from histological examination results. Consumption of this diet may be useful for diabetes mellitus patients in ameliorating diabetes mellitus and its complications

Keywords:

• antioxidant enzymes
• diet
• hematological parameters
• Triticum aestivum–based

Declaration of interest

The authors declare no conflicts of interest. The authors alone are responsible for the content and writing of the article.

Additional information

Notes on contributors

B. O. Ajiboye

B. O. Ajiboye, PhD, Biochemistry Lecturer, College of Sciences, Afe Babalola University (specific field: Biochemistry), Department of Chemical Sciences, Ado-Ekiti, Ekiti State, Nigeria.

H. O. B. Oloyede

H. O.B. Oloyede, PhD, Professor of Biochemistry, Faculty of Life Science, University of Ilorin (specific field: Biochemistry), Department of Biochemistry, Ilorin, Kwara State, Nigeria.

M. O. Salawu

M. O. Salawu, PhD, Biochemistry Lecturer, Faculty of Life Science, University of Ilorin (specific field: Biochemistry), Department of Biochemistry, Ilorin, Kwara State, Nigeria.