The anti-Mullerian hormone as a predictor of early pregnancy loss in subfertile women

ABSTRACT

The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies by ultrasound within 1 year of measuring serum AMH level were retrospectively analyzed. Among 848 patients, 206 women were diagnosed with early pregnancy loss. The mean age of the 848 patients was 35.66 ± 3.61 years (range: 26–46 years), and the mean AMH level was 2.95 ± 1.89 (range: 0.14–8.82 ng/mL). There were no significant differences in gravidity, parity, body mass index (BMI), and previous abortion history depending on early pregnancy loss. However, multivariable logistic regression analysis confirmed that the probability of early pregnancy loss is significantly affected by age (odd ratio, 1.079: 1.025–1.135, P = 0.004) and AMH (odd ratio, 0.885: 0.797–0.982, p = 0.022). According to this study, AMH level and age are both powerful predictors of early pregnancy loss. While chronological age is already well known as a factor related to early pregnancy loss, AMH was also considered when individualizing risk prediction for early pregnancy loss.

KEYWORDS:

• Anti-Mullerian hormone (AMH)
• age
• early pregnancy loss
• subfertility

Ethics approval

This study was approved by the institutional review board of CHA Gangnam Medical Center, CHA University, Seoul, Korea. (GCI-19-23)

Authors’ contributions

Contributed to the study design, acquisition of data, analysis and interpretation of data, drafting of manuscript, and critical revision of the manuscript: SH; supervised the analysis, helped in the study coordination and the data collection: EC, EH; took part in the discussion and data analysis: SM, SK, MK, DC; participated in the design of the study and drafted the manuscript: SS, HP. All authors have read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.