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Original Articles

Residue depletion of sulfachlorpyrazine in edible tissues of broiler chickens

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Pages 272-277 | Received 24 Aug 2012, Accepted 29 Oct 2012, Published online: 03 Dec 2012
 

Abstract

The residue depletion profile of sulfachlorpyrazine was studied in healthy broilers after oral administration of Sulfatyf®, given at a dose of 50 mg sulfachlorpyrazine (SCP) per kg body weight once daily for 3 consecutive days. Twenty-five medicated broilers were slaughtered on the 5th, 10th, 14th and 16th day of post-medication, and muscle, fat with skin, liver and kidney tissues were sampled and analysed using an high-performance liquid chromatography (HPLC) method with satisfactory recovery (74.5% ± 2.9%) and specificity. The estimated values of LOD and LOQ were 18.40 and 55.70 ng ml−1, respectively. On the 5th and 10th day of post-medication, the concentrations of SCP residue in all samples examined were higher than the corresponding MRLs established by the European Union and the highest SCP concentrations were measured in muscle. A maximum withdrawal time of 14 days was calculated to ensure consumer safety.

Acknowledgements

The authors thank M. Osypiuk for technical assistance and for supporting this study.

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