Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry

Huimin WeiMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Yanfei TaoMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Dongmei ChenMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Shuyu XieMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Yuanhu PanMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Zhenli LiuMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Lingli HuangMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaView further author information

Zonghui YuanMOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, ChinaCorrespondence[email protected]
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Abstract

A rapid multi-residue screening method that includes 128 veterinary anti-parasitic drugs and metabolites in meat of chicken, porcine and bovine has been developed. The scope of the method focuses on screening the following main families of veterinary anti-parasitic drugs: avermectines, benzimidazoles, the polyether ionophore, anti-tapeworm, anti-trematode, anti-piroplasmosis and chemical classes of coccodiostats. The method described a QuEChERS sample preparation procedure prior to LC-MS/MS analysis. The modified QuEChERS technology minimises sample complexity and ion suppression effects. The method was validated according to European Union guidelines (2002/657/EC) for a quantitative screening method. The validation results demonstrate that the described LC-MS/MS method provides sensitive, repeatable and meets residue screening monitoring requirements.

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Funding

The authors thank the Special Fund for Agro-scientific Research in the Public Interest [grant number 201203040] which enabled this work to be carried out.

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Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry

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Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry

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