248
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement

, , , , &
Pages 179-185 | Received 14 Sep 2015, Accepted 24 Nov 2015, Published online: 24 Dec 2015
 

ABSTRACT

A novel tadalafil analogue found in a dietary supplement by routine drug-adulteration screening was isolated by column chromatography and HPLC. On the basis of extensive 1D- and 2D-nuclear magnetic resonance (NMR), infrared (IR) and mass spectral analyses, the structure of the new compound YJ-02 was established as 6‐(benzo[d][1,3]dioxol‐5‐yl)‐2,3,6,7,12,12a‐hexahydro‐2‐(1E,2E)‐3‐phenylallylidene)amino)pyrazino[1ʹ,2ʹ:1,6]pyrido[3,4‐b]indole‐1,4‐dione. Its common name is N-phenylpropenyltadalafil.

Additional information

Funding

This work was supported by the Taiwan Food and Drug Administration Fund.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.