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Articles

Identification of a new type tadalafil analogue in a supplement product

, , , &
Pages 1233-1237 | Received 11 Jan 2018, Accepted 13 Mar 2018, Published online: 30 May 2018
 

ABSTRACT

A novel compound structurally similar to tadalafil was found in a dietary supplement by adulterants screening test and isolated by column chromatography. After analysis by accurate mass, nuclear magnetic resonance (NMR) and X-ray, the structure of this novel tadalafil analogue was determined as (5R, 16R)-5-(1,3-benzodioxol-5-yl)-2- (3-ethypentan-3-yl)-15,16-dihydro(1H-imidazo[1,5-a]pyrido)[3,4-b]indol-1,3-dion

GRAPHICAL ABSTRACT

Acknowledgements

The authors gratefully thank the financial support from Taiwan Food and Drug Administration and the technical assistance of NMR and X-ray data acquirement by the instrumentation Center of National Taiwan University.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Taiwan Food and Drug Administration (MOHW103-FDA-72015).

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