The effects of heat applications on macrocyclic lactone-structured antiparasitic drug residues in cows’ milk

ABSTRACT

The study aimed to evaluate the effects of heat on macrocyclic lactone residues in cows’ milk. Ivermectin, abamectin, doramectin, eprinomectin and moxidectin were added to raw milk in three concentrations. The milk was then pasteurised (40 seconds at 74°C or 1 minute at 80°C) and boiled (10 minutes at 100°C). The analyses were performed with a validated method: LC-MS/MS. Thermal treatment resulted in a statistically significant decrease in the abamectin, eprinomectin, and moxidectin concentrations in the milk; however, the residues did not completely degrade. Boiling resulted in a greater decrease in the moxidectin concentrations than was observed with pasteurisation. The high pasteurisation and boiling processes had a greater effect on the eprinomectin residues than did the low pasteurisation process. The pasteurisation and boiling processes did not have an effect on the doramectin and ivermectin. The study concluded that the macrocyclic lactones are generally resistant to such processes.

KEYWORDS:

• Avermectin
• cream
• milbemycin
• milk
• pasteurisation
• sterilisation

Declaration of Interest

Authors do not have conflicts of interests. This study was summarized from same named PhD thesis by Burcu AVCI, Graduate School of Health Sciences, Ankara University.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.