ABSTRACT
Gaining a complete understanding of transmission risk factors will assist in efforts to reduce new HIV infections, especially within the disproportionally affected population of men who have sex with men (MSM). We recently reported that the fecal microbiota of MSM elevates immune activation in gnotobiotic mice and enhances HIV infection in vitro over that of fecal microbiota from men who have sex with women. We also demonstrated elevation of the gut homing marker CD103 (integrin αE) on CD4+ T cells by MSM-microbiota. Here we provide additional evidence that the gut microbiota is a risk factor for HIV transmission in MSM by showing elevated frequencies of the HIV co-receptor CCR5 on CD4+ T cells in human rectosigmoid colon biopsies. We discuss our interest in specific MSM-associated bacteria and propose the influx of CD103+ and CCR5+ CD4+ T cells into the colon as a potential link between the MSM microbiota and HIV transmission.
Acknowledgments
This work was supported by R01DK104047 (B.P. and C.L.), R01DK108366 (B.P., C.L., and T.C.), R01HL138639 (B.P., C.L., and T.C.) and by the Colorado Clinical and Translational Sciences Institute (UL1TR00005). We would particularly like to thank the study participants.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest to disclose.