Anti-synthetase syndrome in a patient with recurrent episodes of pulmonary embolism: a case report

Moemen Eltelbanya Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA

Yuting Huanga Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USACorrespondence[email protected]

Preetinder Sandhua Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA

Abdul Akbaryehb American University of Antigua, College of Medicine, Osbourn, Antigua and Barbuda

Nzube Ilohb American University of Antigua, College of Medicine, Osbourn, Antigua and Barbuda

Dena H. Trana Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA

Jamal Mikdashia Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA

Iram Bakhtawara Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA

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ABSTRACT

Anti-synthetase syndrome (ASS) is characterized by myositis that is associated with progressive interstitial lung disease (ILD). The prognosis of the disease is affected by the type and degree of pulmonary involvement. We report a rare case of ASS with positive Anti-EJ antibody presenting with a combination of recurrent deep vein thrombosis/pulmonary embolism (DVT/PE) and progressive ILD. This case demonstrates the delayed diagnosis of ASS and the association of thromboembolic disease and ASS. Physicians should have a high index of suspicion for ASS, as early diagnosis and management alters the morbidity and prognosis of patients with ASS.

Abbreviations

ASS: Anti-synthetase syndrome; Ab: Antibody; Ag: Antigen; ANA: Anti-nuclear antibodies; CK: Creatine kinase; CRP: C-reactive protein; DVT: Deep Vein Thrombosis; ESR: Erythrocyte Sedimentation Rate; ILD: Interstitial lung disease; PE: Pulmonary Embolism; CTA: CT Angiography

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Anti-synthetase syndrome in a patient with recurrent episodes of pulmonary embolism: a case report

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Anti-synthetase syndrome in a patient with recurrent episodes of pulmonary embolism: a case report

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