Microvesicles: ROS scavengers and ROS producers

ABSTRACT

This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly and/or indirectly modify the ROS content in the extra- as well as the intracellular compartments. In this regard, microvesicles contain a pro-oxidant or antioxidant machinery that may produce or scavenge ROS: direct effect. This mechanism is especially suitable for eliminating ROS in the extracellular compartment. Endothelial microvesicles, in particular, contain a specific and well-developed antioxidant machinery. On the other hand, the molecules included in microvesicles can modify (activate or inhibit) ROS metabolism in their target cells: indirect effect. This can be achieved by the incorporation into the cells of ROS metabolic enzymes included in the microvesicles, or by the regulation of signaling pathways involved in ROS metabolism. Proteins, as well as miRNAs, are involved in this last effect.

KEYWORDS:

• Extracellular vesicles
• microvesicles
• reactive oxygen species

Disclosure statement

The authors report no potential conflict of interest.

Additional information

Funding

This work was supported by the Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder European Grant (PI14/00806; PI17/01029; ISCIII-FEDER), P11-CTS7352, Santander/UCM PR41/17-20964, “Sociedad Española de Nefrologia”, and “Proyectos de Investigación del Programa Propio de la UAH”: UAH-GP2018-4 and CCG2018/BIO-010.