Abstract
Objective: This study aims to investigate the level of peripheral blood mononuclear cells and their ratios which may point to the immunological mechanisms involved in the etiopathogenesis of ASD.
Method: The complete blood count parameters of the 45 ASD cases were compared with those of healthy controls.Childhood Autism Rating Scale (CARS) was performed to measure the disease severity.
Results: The monocytes of ASD group were significantly higher; and the lymphocyte-to-monocyte ratio (LMR) was lower than the controls’. LMR and neutrophil-to-lymphocyte ratio were found to be predictors of ASD. The decrease in LMR (B: −0.744; P=0.035; CI: −1.431 to −0.056) and the increase in age (B: 0.432; P=0.045; CI: 0.011–0.853) were related to high CARS scores in linear regression analyses.
Conclusions: The results of this study support the role of altered immune cell counts and ratios in ASD. A high monocyte level and low LMR may have diagnostic values in autism.
Acknowledgments
There is not any source of funding in this research. The data collected retrospectively from the database of the Education and Research Hospital.