Aminoglycoside-induced hearing deficits – a review of cochlear ototoxicity

Abstract

This article aims to inform the reader about current knowledge of the effects of aminoglycosides on hearing. The hearing loss caused by aminoglycosides is permanent and can negatively affect the individual’s quality of life. Although treatment with aminoglycosides cannot be avoided in some instances, timely intervention can minimise the impact of the hearing loss on the individual’s everyday life. The discussion includes the incidence of aminoglycoside-induced hearing loss and predisposing factors. In addition, monitoring and management of cochlear ototoxicity is described.

Keywords:

• amikacin
• aminoglycosides
• cochleotoxicity
• hearing loss
• kanamycin
• ototoxicity

Additional information

Funding

Funding. This work was supported by University of Cape Town.