https://orcid.org/0000-0003-1130-8783
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ABSTRACT
Introduction
In spite of the substantial advances in clinical practice, Gastric cancer (GC) remains the third leading cause of cancer death worldwide. The incidence of drug resistance remains a hindrance to effective treatment for GC. Although the molecular mechanisms of chemoresistance have broadly studied, the gene regulation and expression mechanisms of miRNA have not entirely understood.
Methods
Online databases of PubMed, Scopus, Google Scholar, and Embase databases were searched to retrieve relevant publications. The following keywords were used: MicroRNA, Non-coding RNA, miRNA, Gastric cancer, drug resistance, and chemoresistance.
Results
miRNAs play a pivotal role in the initiation, progression of tumor and metastasis, as well as in the development of pathways mediating resistance to chemotherapy in GC. Unluckily, to date, there is no consistent, reliable biomarker available to predict the response of chemotherapy before the start of the treatment.
Discussion
In this review, we would like to provide an overview of the miRNAs and miRNA facilitated chemoresistance machinery in GC to develop a personalized treatment to overcome GC drug resistance.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
Notes on contributors
Henu Kumar Verma
Henu Kumar Verma has completed his M.Sc in Medical Biotechnology from Pt. J.N.M. Medical College, Raipur, India. Mr. Verma is International Marie Curie Ph.D fellow at Institute of Endocrinology and oncology CNR, Naples, Italy. He has published more than 25 peer-reviewed international papers and a book chapter in reputed journals. His field of specialization is Molecular Biology, Genetics, Immunology, Cancer Diagnostics and Cell Biology.
Yashwant Kumar Ratre
Yashwant kumar Ratre has completed his M.Sc in Medical Biotechnology from Pt. J.N.M. Medical College, Raipur, India. Currently Mr. Ratre is Ph.D fellow at Guru Ghasidas University, Bilaspur, India. He has published 5 peer-reviewed international papers in reputed journals. His field of specialization is Molecular Biology and Genetics.
Pellegrino Mazzone
Dr. Pellegrino Mazzone has completed his Ph.D. in Bioinformatics and Life Science from the University of Studies of sannio, Benevento. Mazzone has joined Biogem scientific research lab, Italy as a postdoctoral fellow in 2014. He has published more than 12 peer-reviewed international papers in reputed journals. His field of specialization is Cell Biology, Immunology, Cancer Diagnostics and Molecular Biology
Simona Laurino
Dr. Simona Laurino has completed her Ph.D. in Molecular Life Science and Medicine. Laurino has joined IRCCS Centro di Riferimento Oncologico della Basilicata (CROB) as a postdoctoral fellow in 2017. She has published more than 15 peer-reviewed international papers in reputed journals. His field of specialization is Molecular Biology, Cancer Biology, Cancer Diagnostics, and Cell Biology.
L. V. K. S. Bhaskar
Dr. L.V.K.S. Bhaskar is a Professor of Zoology and Dean of the School of Life Sciences at Guru Ghasidas Central University, Chhattisgarh. Prior to this appointment, Dr. Bhaskar was the Senior Scientist at Sickle Cell Institute, Chhattisgarh. Dr. Bhaskar was awarded the Prof. Pampapathi Rao memorial Gold Medal in 2003. Dr. Bhaskar is an active member of several genetics and biotechnology-related professional and academic bodies. He has conducted research to explore molecular basis of alcoholism, genetics of complex human diseases, population genetics, and cancer biology. Dr. Bhaskar has published more than 150 research papers in reputed national and international journals. Dr. Bhaskar has been a regular reviewer for several national and international journals and also serves on the editorial board of various journals.