Association of high sensitive C reactive protein and dialysis adequacy with uremic pruritus in hemodialysis patients

ABSTRACT

Introduction

Uremic pruritus is one of the most common and complicated symptom affecting hemodialysis patients, it can be persistent, distressing and having a significant impact on the quality of life. We aimed to study the relationship between high sensitive C reactive protein and adequacy of dialysis with uremic pruritus in hemodialysis patients.

Patients and Methods

In this Case control study one hundred prevalent hemodialysis patients were enrolled from hemodialysis units in Ain Shams University hospitals, fifty of them had pruritus and the other fifty patients had no pruritis, all of them underwent urea reduction ratio for dialysis adequacy assessment, pruritus assessment by using visual analog scale and high sensitive C reactive protein serum level.

Results

Uremic pruritus has statistically significant negative correlation with urea reduction ratio and consequently with dialysis adequacy. However, uremic pruritus has statistically significant positive correlation with highly sensitive C reactive protein serum levels in hemodialysis patients.

Conclusion

Inadequate hemodialysis and increased hsCRP serum level play an important role in aggravating intensity and severity of uremic pruritus.

KEYWORDS:

• C reactive protein
• dialysis adequacy
• uremic pruritus
• hemodialysis

Disclosure statement

The authors report no conflict of interest.

Additional information

Notes on contributors

Iman I. Sarhan

Professor Dr. Iman Ibrahim Sarhan, Professor of Internal Medicine and Nephrology,  Ain Shams University , Faculty of Medicine, member of Egyptian Society of Nephrology and transplantation.

Mona Abdel-Halim Ibrahim

Dr Mona Abdelhalim Ibrahim, Lecturer of Dermatology, Venerology and andrology Ain Shams University, member of International Society for cutaneous lymphoma.

Nahla M. Teama

Dr Nahla Mohamed Teama, Lecturer of Internal Medicine and Nephrology  Ain Shams University, Faculty of Medicine, member of Egyptian Society of Nephrology  and Transplantation.