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ABSTRACT
Background
Elevated oxidant levels and low antioxidant levels in patients with end-stage renal disease (ESRD) play a significant role in the development of endothelial dysfunction, atherogenesis and cardiovascular disease (CVD). A deficiency in vitamin D (Vit.D) is also suggested to be responsible for the generation of oxidative stress (OS) and CVD. Among dialysis patients, conflicting data exist concerning the relationship between hepatitis C virus (HCV) infection and OS. We studied the relationship between 25Vit.D level, HCV infection, and plasma 8 iso-prostaglandin F2 α (8-ISO-PGF2α) as an OS marker in an Egyptian hemodialysis (HD) cohort.
Methods
One hundred and twenty ESRD patients on HD were initially recruited to the study but only 88 patients have met the inclusion and none of the exclusion criteria. Midweek predialysis session blood samples were collected for the measurement of 25(OH) Vit.D, plasma 8-ISO-PGF2α, high sensitivity C – reactive protein (hs-CRP), and intact parathyroid hormone (intact PTH). Patients were stratified into two groups according to the presence or absence of serum antibodies against HCV and their plasma 8-ISO-PGF2α were compared.
Results
Vit.D deficiency was noted in 93% of the participants; the median 8-ISO-PGF2α level was 382 pg/mL. No significant correlation between Vit.D and 8-ISO-PGF2α levels was found. Thirty-two participants (36%) were HCV+ and their 8-ISO-PGF2α levels were significantly lower relative to in the seronegative group (median 171 vs. 647 pg/mL; P < 0.006).
Conclusion
In this Egyptian HD cohort, Vit D deficiency was highly prevalent, yet failed to show any correlation with F2-isoprostanes. HCV+ HD patients might be shielded from OS.
“Consent to participate”
All of the included patients signed an informed consent form after receiving full information about the study.
“Data availability”
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Notes on contributors
Mahmoud S. AbdElHady
Mahmoud S. AbdElHady Assistant lecturer Internal Medicine Nephrology Department Kafrelsheikh university Egypt.
Sara T Ibrahim
Sara T Ibrahim, MDPhD is a Lecturer of Internal Medicine and Nephrology, Faculty of Medicine Alexandria University since April 2020. She is also Assistant of Medical Director of Internal Medicine Hospital (Alexandria Main University Hospitals). She finished her residency program in Alexandria Main University Hospital. Her main research interests are autoimmune renal diseases and chronic kidney diseases. She is member of the international society of nephrology and the Egyptian society of nephrology.She authored 7 peer reviewed publications in high indexed international journals and was cited 10 times till the end of 2021.
Ahmed Adam
Ahmed Adam Professor of Internal Medicine and Nephrology in Faculty of Medicine, Alexandria University, Egypt.Head of the Internal Medicine and Nephrology, Dialysis, Transplantation Department in AUH.Former Senior Registrar in SKI - UKFormer Research Fellow in MN, and KY – USASupervisor of more than 40 MS and Ph D ThesisPublications more than 50 in the field of Kidney, Dialysis, Hypertension and Transplantation.Research interest within the Transplantation field in the area of Infections including BK, CMV, Long term outcome and Rejection.
Abelaziz Elnekidy
Abdelaziz ELnekidy Professor of Radiodiagnosis Faculty of Medcine Alexandria University Egypt. He had many publications in high indexed journals .
Neveen Lewis
Neveen Lewis Assistant professor of Clinical Pathology Faculty of Medcine Alexandria University Egypt. spechial interest in kidney disease research and had many international publications.
Rasha Ibrahim Gawesh
Rasha Ibrahim Gawish Lecturer of internal Medicine Nephrology Department Faculty of Medicine Alexandria University Egypt. she had more than 4 publications in the field of nephrology.