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ABSTRACT
During transcription, RNA polymerase moves downstream along the DNA template and maintains a transcription bubble. Several recent structural studies of transcription complexes with a complete transcription bubble provide new insights into how RNAP couples the nucleotide addition reaction to its directional movement.
Abbreviations
| BH | = | bridge helix |
| NTP | = | nucleoside triphosphate |
| PPi | = | pyrophosphate |
| RNAP | = | RNA polymerase |
| TL | = | trigger loop |
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Funding
This work was supported by NIH grant GM22778 (to T.A.S.). T.A.S. is an investigator of the Howard Hughes Medical Institute.