http://orcid.org/0000-0001-6861-3143
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ABSTRACT
Transcription factors (TFs) are among the most frequently detected targets of sumoylation, and effects of the modification have been studied for about 200 individual TFs to date. TF sumoylation is most often associated with reduced target gene expression, which can be mediated by enhanced interactions with corepressors or by interference with protein modifications that promote transcription. However, recent studies show that sumoylation also regulates gene expression by controlling the levels of TFs that are associated with chromatin. SUMO can mediate this by modulating TF DNA-binding activity, promoting clearance of TFs from chromatin, or indirectly, by influencing TF abundance or localization.
Disclosure of potential conflicts of interest
No potential conflict of interest was reported by the authors
Acknowledgments
We thank Patricia Richard (Columbia University) for comments and suggestions.
Funding
This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada (NSERC; grant number RGPIN-04208–2014) and the Canadian Institutes of Health Research (CIHR; grant number MOP-142282) to E.R.