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All Life Volume 13, 2020 - Issue 1
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Perspectives

Positive transcription elongation factor b and its regulators in development

Yan WangDepartment of Pediatrics, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-5076-4282
ORCID Icon &
Tong QiuDepartment of Pediatrics, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence[email protected]
Pages 23-33 | Received 30 Apr 2019, Accepted 29 Aug 2019, Published online: 12 Sep 2019
 
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Abstract

Positive transcription factor b (P-TEFb) has emerged as a general and essential factor to release RNA polymerase II from promoter-proximal pausing. Recruitment of P-TEFb by various master developmental regulators seems to be a common theme to allow for coordinated gene expression. The biological outcome is highly dependent on the cellular context as well as the nature of the transcription factor that recruits P-TEFb. Understanding the physiological functions of P-TEFb and its regulators will certainly have implications in human diseases such as cancer.

Acknowledgment

This work was supported by West China Second University Hospital.

Disclosure statement

No potential conflict of interest was reported by the authors.

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