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HIF-1 is a critical target of pancreatic cancer

Article: e1026535 | Received 27 Feb 2015, Accepted 27 Feb 2015, Published online: 27 Jul 2015
 

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal digestive tract malignancies. Hypoxia-inducible factor (HIF-1) is over-expressed in pancreatic cancer and associated with poor prognosis. During the past several years, we focused on identifying the function of HIF-1 and the antitumor effect of HIF-1 inhibitors on PDAC, especially in regards to immunogenic cell death.

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

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