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Research Papers

Research and development of therapeutic mAbs: An analysis based on pipeline projects

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Pages 2769-2776 | Received 01 May 2015, Accepted 15 Jul 2015, Published online: 23 Dec 2015
 

Abstract

As the subject of active research and development (R&D) in recent decades, monoclonal antibodies have emerged among the major classes of therapeutic agents for treatment of many human diseases, especially cancers, infections, and immunological disorders. This article surveys the landscape of R&D projects of therapeutic monoclonal antibodies (mAbs), which are mostly used for disease immunotherapy, from a number of perspectives, including therapeutic indications, development phases, participants, and citation of related patents. The results of this research can be used as a reference resource for pharmaceutical researchers, investors, and policymakers in the field of therapeutic mAbs

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Supplemental Material

Supplemental data for this article can be accessed on the publisher's website.

Note

aIndications of mAb-related R&D programs were classified for simplicity into six therapeutic categories (anti-cancer, immunological, anti-infective, neuropharmacological, cardiovascular and cerebrovascular, and others). Anti-cancer indications included mAbs for treating various types of cancers; anti-infective indications included mAbs against viral infection, bacterial infection, or fungal infection; immunological indications were assigned to mAbs as a treatment for transplant rejection, inflammation, systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, or several other autoimmune diseases.

Funding

We thank the University of Macau for financial support for this research by the project MYRG2015-00172-ICMS-QRCM.

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