ABSTRACT
We aimed to describe the impact of pertussis on adolescents, adults, and older adults over 2007–2018 in selected Latin American countries by reviewing the literature. We searched the Medline, Embase, Scopus, LILACS, Scielo, Google Scholar, CAPES Journals Web-portal, and Cochrane databases for observational epidemiological studies, clinical trials, and systematic reviews of primary studies. Data were extracted and analyzed for all individuals aged ≥10 years. Of 6,891 studies identified only 25 were eligible. Studies were conducted in Brazil (14), Argentina (4), Colombia (4), Mexico (2) and Chile (1). Epidemiological data among target population were limited. No studies clearly assessed the status of asymptomatic or oligosymptomatic B. pertussis carriers in these age groups. Among all pertussis cases identified, the percentage of patients ≥10 years-old ranged between 2.1% and 66.7% depending on country and sample characteristics. The definition of cases, diagnostic methods, and age groups were not consistent across studies.
Acknowledgments
Authors would like to thank Business & Decision Life Sciences platform for editorial assistance and manuscript coordination, on behalf of GSK. Pierre-Paul Prévot coordinated manuscript development and editorial support. The authors also thank Athanasia Benekou (Business & Decision Life Sciences, on behalf of GSK) for providing medical writing support.
Contributorship
All authors participated in the design or implementation or analysis, and interpretation of the study; and the development of this manuscript. All authors had full access to the data and gave final approval before submission.
Disclosure of potential conflicts of interest
Ariane de Jesus Lopes de Abreu was employed by Shift Gestão de Serviços and reports to a third part employee of the GSK group of companies during the conduction of this study. Bárbara Emoingt Furtado is an employee of the GSK group of companies. Eliana Nogueira Castro de Barros was an employee of the GSK group of companies at the time the manuscript was being drafted. Barbara Furtado hold shares in the GSK group of companies. Eduardo Barbosa Coelho, Altacilio Aparecido Nunes and Anderson Soares da Silva report their institution received funding from the GSK group of companies to complete the work disclosed in this manuscript, as well as funding outside the submitted work.
Supplementary material
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