Intention to accept pertussis vaccination among Chinese people older than age 5

ABSTRACT

Background: The intention of Chinese people older than age 5 to accept the pertussis vaccination is unknown, which is important for the future design of an effective pertussis vaccination program in China.

Method: We conducted a cross-sectional survey among people older than age 5 in China. A 24-item questionnaire was used to explore the determinants of intention to accept a pertussis vaccination, and for children and adolescents (≦15 years old), their guardian was required to help answer the questionnaire on their behalf. Univariate and multivariate logistic regression was used to analyze the influencing factors of intention.

Results: A total of 3,041 individuals participated in our survey and 3025 completed the questionnaire, among which 1938 (64.07%) reported a positive intention to be vaccinated. A multiple logistic regression analysis revealed that the main positive factors for the intention to accept pertussis vaccination were younger age (Odd ratio [OR] 0.838, P < .001), higher educational attainment (OR 1.171, P = .002), no hospitalization because of the most recent cough (OR 2.468, P < .001), awareness about pertussis (OR 1.958, P < .001), and consideration of pertussis vaccination to be safe (OR 1.450, P = .026).

Conclusion: There is a relatively high level of intention to receive the pertussis vaccine among people older than age 5 in China. Future pertussis vaccination strategies geared at them should consider focusing on middle-aged and older individuals and those with a low education as well as strengthen the promotion of disease characteristics, vaccine effectiveness, and safety.

KEYWORDS:

• Pertussis
• vaccination program
• cross-sectional survey
• intention

Abbreviations

OR	=	odds ratio
CI	=	confidence interval;
DTaP	=	diphtheria, tetanus, pertussis vaccine
Tdap	=	tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis
PPS	=	Probability proportionate to size sampling
CDC	=	Center of Disease Control and Prevention
ACIP	=	Advisory Committee on Immunization Practices

Acknowledgments

We thank all investigators in the field for their super work. We sincerely thank Dr. Jianxin Yu (Chinese Center for Disease Control and Prevention) for his critical review and help to design this study.

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Supplementary material

Supplemental data for this article can be accessed on the publisher’s website.

Additional information

Funding

This work was supported by the Medical Health Science and Technology Project of Zhejiang Province, China under Grants [number 2019KY052 and 2019KY059], National Natural Science Foundation of China (NSFC) [grant number 81973106], Beijing Municipal Natural Science Foundation [grant number 19L2060].