Coronavirus (SARS-CoV-2): a systematic review for potential vaccines

ABSTRACT

COVID-19 is an international public health emergency in need of effective and safe vaccines for SARS-CoV-2. A systematic review has been done to analyze the availability, development and status of new COVID-19 vaccine candidates as well as the status of vaccines for other diseases that might be effective against SARS-CoV-2 infection. PubMed, MEDLINE, EMBASE, Science Direct, Google Scholar, Cochrane library, ClinicalTrials.gov, Web of Science and different trial registries were searched for currently available and probable future vaccines. Articles and ongoing clinical trials are included to ascertain the availability and developmental approaches of new vaccines that could limit the present and future outbreaks. Pharmaceutical companies and institutions are at different stages of developing new vaccines, and extensive studies and clinical trials are still required.

KEYWORDS:

• SARS-CoV-2
• vaccine candidates
• coronavirus
• covid-19
• clinical trial
• vaccine development

Acknowledgments

The authors acknowledge staff of Virology Division, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India for help and support.

Authors’ information (optional)

Dr. Mihir Bhatta [Technical Officer, National HIV Reference Laboratory], Ms. Srijita Nandi [Research Officer, National HIV Reference Laboratory], Dr. Shanta Dutta [Scientist-G & Director, ICMR-National Institute of Cholera & Enteric Diseases] and Dr. Malay Kumar Saha [Scientist-F, Virology Division; In-Charge, National HIV Reference Laboratory; Focal Person, Regional Institute: HIV Surveillance] ICMR-National Institute of Cholera & Enteric Diseases P-33, CIT Road, Scheme - XM, Beliaghata, Kolkata-700 010, West Bengal, India.

Ethics approval and consent to participate

Not applicable as published data were analyzed for this study.

Availability of data and material

All data generated or analyzed are included in this article

Disclosure of potential conflicts of interest

The authors declare that they have no competing interests.

Supplementary material

Supplemental data for this article can be accessed on the publisher’s website at https://doi.org/10.1080/21645515.2020.1865774.

Additional information

Funding

No funding was received for this research

Notes on contributors

Malay Kumar Saha

MB and MKS conceived and designed the study. MB and SD established the search strategy. MB and SN extracted the data. MB, SD, MKS, and SN wrote the article. All the authors read the manuscript before they have given the final approval for publication.