641
Views
1
CrossRef citations to date
0
Altmetric
Research Paper

Quantitative characterization of the T cell receptor repertoires of human immunized by rabies virus vaccine

, , , , &
Pages 2530-2537 | Received 25 Jul 2020, Accepted 16 Feb 2021, Published online: 06 Apr 2021
 

ABSTRACT

Cellular immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the T cell receptor (TCR) repertoire in human after RABV vaccine immunization remained unclear. In this study, we conducted high-throughput sequencing of TCR β chain complementarity determining region 3(CDR3) repertoires in 4 healthy volunteers before and after immunization with RABV vaccine. Our data showed that RABV vaccination changed the TCR diversity and the usage of V/J gene segments, as well as V-J pairing. The high-frequency clonotypes that altered after vaccination were identified. These results may provide us with new insights into T cell receptor condition after RABV vaccination.

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Additional information

Funding

This study was supported by The National Key Research and Development Program of China (国家重点研发计划) [Grant No.: 2016YFD0500405 to Dr. Pingsen Zhao], The National Key Research and Development Program of China [Grant No.: 2017YFD0501705 to Dr. Pingsen Zhao] and Natural Science Foundation of Guangdong Province, China [Grant No.: 2016A030307031 to Dr. Pingsen Zhao].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.