Current status and future prospects of chimeric antigen receptor-T cell therapy in lymphoma research: A bibliometric analysis

ABSTRACT

CAR-T cell therapy, a novel therapeutic approach that has attracted much attention in the field of cancer treatment at present, has become the subject of many studies and has shown great potential in the treatment of hematological malignancies, such as leukemia and lymphoma. This study aims to analyze the characteristics of articles published on CAR-T cell therapy in the lymphoma field and explore the existing hotspots and frontiers. The relevant articles published from 2013 to 2022 were retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, Bibliometric online analysis platform, Microsoft Excel, and R software were used for bibliometric analysis and visualization. The number of publications related to the research has been increasing year by year, including 1023 articles and 760 reviews from 62 countries and regions, 2092 institutions, 1040 journals, and 8727 authors. The United States, China, and Germany are the main publishing countries in this research field. The top 10 institutions are all from the United States, the journal with the highest impact factor is BLOOD, the author with the most publications is Frederick L Locke, and the most influential author is Carl H June. The top three keywords are “Lymphoma,” “Immunotherapy,” and “Therapy.” “Maude (2014)” is the most cited and strongest burstiness reference over the past decade. This study provides a comprehensive bibliometric analysis of CAR-T cell therapy in lymphoma, which can help researchers understand the current research hotspots in this field, explore potential research directions, and identify future development trends.

KEYWORDS:

• CAR-T cell therapy
• chimeric antigen receptor (CAR)
• lymphoma
• bibliometric analysis
• CiteSpace
• VOSviewer

Acknowledgments

I am grateful for the academic assistance provided by Shengxiang Hu from the School of Computer Engineering and Science at Shanghai University, Danwei Zhao from the West China School of Stomatology at Sichuan University, and Zhigang Zhu from the Xiangya School of Stomatology at Central South University. Additionally, I thank my family for their understanding and support of my academic work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

CRediT authorship contribution statement

All authors contributed to the conceptualization and design of the study. Hui Zhou and Ling Xiao participated in the conceptualization and design of the study. Lijia Ou, Chang Su, and Liang Liang contributed to the conceptualization of the study, implementation of the research, and statistical analysis of the data. Qintong Duan, Yufeng Li, and Hui Zang collected and organized the data. Lijia Ou, Yizi He, Ruolan Zeng, and Yajun Li designed and produced the figures and tables. Lijia Ou completed the manuscript writing. All authors participated in the manuscript revision and read and approved the final manuscript for submission.

Data availability statement

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

Additional information

Funding

This work is supported by Hunan Provincial Natural Science Foundation of China [grant numbers 2021JJ40320, 2021JJ30425, 2022JJ40243, 2022JJ30026, 2022JJ30789]; Changsha Municipal Natural Science Foundation [grant numbers kq2014206], and Natural Science Foundation of Hunan Province National Health Commission [grant numbers 20201659]; the “Scientific Research Climbing Plan” of Hunan Cancer Hospital [grant number ZX2020003]; Hunan Provincial Science and Technology Department Project [grant number 2021SK4015]; Project of Health Commission of Hunan Province [grant numbers 202203045455].