A bibliometric analysis of vaccination against atherosclerosis

ABSTRACT

A growing body of research indicates the promising potential of vaccines in both preventing and treating atherosclerosis (AS). To gain a comprehensive understanding of the current research landscape and emerging trends in this field, this study conducted a bibliometric analysis of publications on AS vaccines using the Web of Science Core Collection (WoSCC) database, based on the “bibliometric” R package and VOSviewer software. From 1991 to 2024, a total of 462 publications were identified in the WoSCC. The United States appeared as the leading contributor in terms of both total publications and citations. The Vaccine journal exhibited the highest publications output. Nilsson J from the Lund University in Sweden was the author with the most published articles, total citations and Hirsch index (H-index). Keywords analysis and thematic maps analysis revealed the passive immunotherapy (AS protective antibodies vaccines) was a hot mature theme, the active immunotherapy (AS antigens vaccines) was an emerging and booming theme, while the efficacy and safety of AS vaccines was a niche and well-developed theme. These findings offered valuable insights into the AS vaccination and provided guidance for future research in this domain.

KEYWORDS:

• Vaccines
• atherosclerosis
• antigen
• antibody
• adjuvant
• research trends
• research hotspots
• bibliometrics

Acknowledgments

We highly appreciate the support from Beijing University of Chinese Medicine and Guang ‘anmen Hospital of China Academy of Chinese Medical Sciences.

Disclosure statement

No potential conflict of interest was reported by the authors.

Contributor statements

All authors contributed to the study conception and design. Bochao Jia, Rui Wei, Chenlu Yuan: article design and writing. Tao Cheng, Shuai Shi and Yuguang Chu: data acquisition and analysis. Yuanhui Hu: article ideas and revision suggestions. All authors participated in the manuscript revision and approved the final manuscript for submission.

Data availability statement

The data supporting the results of this study can be obtained from the corresponding authors upon reasonable request.

Additional information

Funding

This work was supported by [Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences] under Grant [CI2021A03801; CI2021A01604].