Prognostic significance of microRNA miR-24 in cancers: a meta-analysis

ABSTRACT

The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies that evaluated the prognostic value of miR-24 in tumors were included. The hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CI) were used to evaluate survival outcomes and clinical characteristics. All data analyses were implemented using STATA 12.0 software. A total of 17 studies from 15 articles involving 1705 patients were collected for the meta-analysis. The pooled analysis revealed that elevated miR-24 expression was obviously associated with poor overall survival (OS) (HR = 1.66, 95% CI: 1.20–2.31). Furthermore, we also found that elevated miR-24 expression was positively correlated with tumor size (large or small) and tumor stage (III–IV vs I–II). Elevated miR-24 expression indicates poor prognosis and may be a promising prognostic marker in different cancers. Our findings needed to be verified through further investigations.

KEYWORDS:

• mir-24
• prognosis
• cancer
• meta-analysis

Article highlights

1. We revealed that elevated miR-24 expression was significantly associated with poor overall survival in patients with cancers.

2. we found that elevated miR-24 expression was positively correlated with tumor size (large or small) and tumor stage (III–IV vs I–II) in patients with cancers.

3. Elevated miR-24 expression indicates poor prognosis and can serve as an effective prognostic indicator in different cancers.

Abbreviation

HR, hazard ratio; OR, odds ratio; CI, confidence interval; OS, overall survival; DFS/PFS/RFS, disease-free survival/recurrence-free survival/progression-free survival; GC, gastric cancer; LC, lung cancer; CRC, colorectal cancer; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; HCC, hepatocellular carcinoma; NPC, nasopharyngeal carcinoma; TSCC, tongue squamous cell carcinoma; NOS, Newcastle Ottawa scale;

Authors’ contributions

Linsen Ye and Yi Shao designed this study. Rongqiang Liu, Weihao Kong and Shiyang Zheng participated in the literature search, formal analysis, investigation, methodology and writing of the manuscript. Other authors participated in the supervision. All authors approved the final manuscript.

Data availability statement

All data are in the manuscript and can be obtained from the corresponding author.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from National Natural Science Foundation of China [No:81660158, 81460092, 81400372]; Natural Science Key Project of Jiangxi Province [No: 20161ACB21017]; Key Research Foundation of Jiangxi Province [No: 20151BBG70223, 20181BBG70004];