Association between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis

ABSTRACT

The paper aims to assess the association between Hepatitis B Virus infection and colorectal liver metastasis by conducting a meta-analysis. The relevant studies were searched until 24 July 2020, Studies that assessed the correlation between HBV infection and CRLM were recruited. A random effects model was applied to calculate the odds ratio (OR) with 95% confidence interval (CI). All data analyses were performed by STATA 12.0 software. Ten studies involving 17529 participants were included in the study. The results shown that there was obvious association between HBV infection and CRLM (OR: 0.51, 95% CI: 0.28–0.91). The study type and case–control rate may be the main causes of heterogeneity. In addition, HBV infection had no association with extrahepatic metastasis or prognosis of patients with CRLM. Sensitivity analyses confirmed that the results were stable, and Egg’s test indicated that there was no publication bias. Patients with HBV infection have the reduced risk of CRLM.

GRAPHICAL ABSTRACT

KEYWORDS:

• Hepatitis B Virus
• colorectal liver metastasis
• meta-analysis

Abbreviation

HBV, Hepatitis B Virus; CRLM, colorectal liver metastasis; OR, odds ratio; CI, confidence interval; CRC, colorectal cancer; CHB, chronic hepatitis B; NOS, Newcastle-Ottawa Scale.

Disclosure statement

The author declares no conflict of interest.

Availability of data and materials

All data are in the manuscript and can be obtained from the corresponding author.

Authors’ contributions

Tianxing Dai and Linsen Ye contributed to the study inception and design. Rongqiang Liu and Weihao Kong made equally contributions to the literature search, analysis and writing of the manuscript. Mingbin Deng and Guozhen Lin contributed to the study design and study supervision. All authors approved the final version of the manuscript.

Additional information

Funding

This work was supported by grants from Guangdong Basic and Applied Basic Research Foundation [2019A1515110654], the Fundamental Research Funds for the Central Universities [20ykpy38], China Postdoctoral Science Foundation [2019TQ0369, 2020M672987]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.