High expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer

ABSTRACT

Stabilin-2 has been found to regulate the progression of cancer. It was not fully understood whether it shows some roles in non-small-cell lung cancer (NSCLC). We used the immunohistochemical staining to evaluate Stabilin-2 protein expression in formalin-fixed paraffin-embedded tissue of NSCLC patients’ primary lesion. And we carried out χ2 test to detect relationships between Stabilin-2 expression and various clinical factors. Besides, the survival difference between patients with high and low Stabilin-2 expression was also analyzed. The expression of Stabilin-2 was associated with N stage and age. Higher Stabilin-2 expression exists in poorer survival patients. It revealed that Stabilin-2 expression was a significant predictor for both OS and DFS by univariate and multivariate analyses. High stabilin-2 expression in NSCLC predicts poor tumor prognosis.

Graphical abstract

KEYWORDS:

• Stabilin-2
• non-small-cell lung cancer
• prognosis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Highlights

Stabilin-2 was correlated with advanced N stage in lung cancer patients;

High expression of Stabilin-2 predicted poor prognosis in non-small-cell lung cancer patients;

Stabilin-2 can be a potential therapeutic target for non-small-cell lung cancer.

Additional information

Funding

The National Key Research and Development Program of China (2019YFA0801403), National Nature Science Foundation of China (No. 81771660, 81741017) and 5010 Projects at Sun Yat-Sen University (2012006) have provided financial support for this study.