ABSTRACT
Brucella endocarditis is a fatal complication and the most frequent cause of death for human brucellosis. This study aimed to systematically review the literature on the follow-up outcomes of Brucella endocarditis and analyze the determinants affecting the follow-up outcomes. The databases PubMed, Web of Science, Embase, and Cochrane were searched using keywords and suitable combinations. All studies reporting the follow-up outcomes of Brucella endocarditis were included. Finally, a total of 76 studies (207 patients), including cases or case series, were included. The event rate for patients who underwent short- and long-term follow-up was 12.0% (2 relapsed and 1 died) and 8.1% (6 relapsed and 8 died), respectively. The differences in outcomes between different age groups (18–39, 40–59, and ≥60) were significant (P < 0.05, P = 0.035). The outcomes of the 18–39 age group were worse than those of the 40–59 age group (OR, 0.277; 95% CI, 0.103–0.748; P = 0.011). Accordingly, follow-up (both short- and long-term follow-up) is essential for Brucella endocarditis patients, especially for younger patients (18–39 years) in the first 6 months after treatment. The burden of Brucella endocarditis related complications were immense. Further studies are needed to explore age-based epidemiology of Brucella endocarditis and the exact influencing factors of the follow-up outcomes.
Highlights
The high incidence age of human brucellosis varies by region and occupation.
Follow-up outcomes of younger Brucella endocarditis patients may be worse than older patients.
There are no differences between short- and long-term follow-up outcomes of Brucella endocarditis patients.
Author contributions
Xiufeng Li and Yuanzhi Wang conceived and designed the article; Songsong Xie searched literatures; Ping Li, Xiufeng Li and Wenbo Tan analyzed the data; Xiufeng Li wrote the paper. All authors read and approved the final manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Supplementary material
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