![Sample our Engineering & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5933/TOC-Subject-Sample-2021-Engineering-Tech.jpg"})
ABSTRACT
miRNA is a small endogenous RNA and an important regulator of gene expression. miR-4443 is abnormally expressed in 12 diseases including cancer. The expression of miR-4443 is regulated by 3 upstream factors. miR-4443 has 12 downstream target genes. miR-4443 inhibits the expression of its target genes, thereby affecting the migration, proliferation, and invasion of pathological cells. miR-4443 participates in 4 signaling pathways and plays a role in the occurrence and development of several diseases. In addition, miR-4443 can also promote resistance to multiple drugs. Here, this article summarizes the aberrant expression of miR-4443 and its pathogenic molecular mechanisms in human diseases, which provides clues and directions for the follow-up research of miR-4443.
Graphical Abstract
Highlights
Dysregulation of miR-4443 affects the behaviors of diseased cells.
miR-4443 is involved in the regulation of four signaling pathways.
miR-4443 is associated with reduced drug sensitivity in cancer patients.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data Availability statement
All data generated or analyzed during this study are included in the article.
Author contributions
YM, JS, YW, RW and FZ collected and analyzed the literature, drafted the figures and wrote the paper; SD and FZ conceived and gave the final approval of the submitted version. All authors have read and agreed to the published version of the manuscript.