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Abstract
Objective: Reliable assessment of cognitive functions is a challenging task in amyotrophic lateral sclerosis (ALS) patients unable to speak and write. We therefore present an eye-tracking based neuropsychological screening tool based on the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), a standard screening tool for cognitive deficits in ALS. Methods: In total, 46 ALS patients and 50 healthy controls matched for age, gender and education were tested with an oculomotor based and a standard paper-and-pencil version of the ECAS. Results: Significant correlation between both versions was observed for ALS patients and healthy controls in the ECAS total score and in all of its ALS-specific domains (all r > 0.3; all p < 0.05). The eye-tracking version of the ECAS reliably distinguished between ALS patients and healthy controls in the ECAS total score (p < 0.05). Also, cognitively impaired and non-impaired patients could be reliably distinguished with a specificity of 95%. Conclusion: This study provides first evidence that the eye-tracking based ECAS version is a promising approach for assessing cognitive deficits in ALS patients who are unable to speak or write.
Acknowledgements
This work was funded by the Deutsche Forschungsgemeinschaft (DFG) and the Bundesministerium für Bildung und Forschung (BMBF #01GM1103A). This is an EU Joint Programme – Neurodegenerative Disease Research (JPND) project. The project is supported through the following organisations under the aegis of JPND – www.jpnd.eu: Germany, Bundesministerium für Bildung und Forschung (BMBF #01ED1405), Sweden, Vetenskaprådet Sverige, and Poland, Narodowe Centrum Badań i Rozwoju (NCBR).
Declaration of interest
The authors declare no competing interests.