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Scandinavian Journal of Urology and Nephrology Volume 25, 1991 - Issue sup138
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Carcinoma of the urinary bladder

Prophylactic Instillation Therapy of Superficial Bladder Cancer

A randomized study comparing Mitomycin C and Adriamycin with special reference to DNA ploidy

H. GustafsonFrom the Departments of Urology, Danderyd Hospital, Karolinska Hospital, Huddinge Hospital, South Hospital and Medical Radiobiology, Karolinska Institute, Stockholm, Sweden
,
H. WijkstrômFrom the Departments of Urology, Danderyd Hospital, Karolinska Hospital, Huddinge Hospital, South Hospital and Medical Radiobiology, Karolinska Institute, Stockholm, Sweden
,
C. NymanFrom the Departments of Urology, Danderyd Hospital, Karolinska Hospital, Huddinge Hospital, South Hospital and Medical Radiobiology, Karolinska Institute, Stockholm, Sweden
,
J. BrolinFrom the Departments of Urology, Danderyd Hospital, Karolinska Hospital, Huddinge Hospital, South Hospital and Medical Radiobiology, Karolinska Institute, Stockholm, Sweden
,
E. BorgstrômFrom the Departments of Urology, Danderyd Hospital, Karolinska Hospital, Huddinge Hospital, South Hospital and Medical Radiobiology, Karolinska Institute, Stockholm, Sweden
&
B. TribukaitFrom the Departments of Urology, Danderyd Hospital, Karolinska Hospital, Huddinge Hospital, South Hospital and Medical Radiobiology, Karolinska Institute, Stockholm, Sweden
Pages 187-191 | Published online: 30 Mar 2023
 
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Abstract

Sixty patients with Ta and T1 bladder cancer were randomized between treatment with resection only and resection and instillations with either Adriamycin or Mitomycin C. Treatment lasted for one year and patients were evaluated after a mean follow-up of 35 to 47 months if progression had not occurred. Mitomycin C was superior in reducing the recurrence rate. Progressive disease was observed in 17 patients regardless of therapy but in all patients DNA aneuploidy could be identified as a risk factor.

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