Introduction for the special issue on “Tissue Barriers in Inflammation”

Abstract

This issue of Tissue Barriers contains the inaugural special issue devoted to recent advances in barrier function of endothelial and epithelial cells. We used this opportunity to invite experts in vascular endothelial cell biology and epithelial cell biology to comment on critical questions and problems in permeability of organ and tissue barriers, and to provide insight into common areas in these fields, namely how these cells maintain homeostasis and response to injury and infection. To complement these reviews, this issue also contains four research articles that explore specific questions related respiratory and intestinal epithelial cell function.

Keywords:

• Barrier
• endothelium
• epithelium
• cytokines
• inflammation
• leukocytes

Abbreviations:

• IBD, inflammatory bowel disease; AJ, adherens junction; TJ, tight junction; PKC, protein kinase C; LPS, lipopolysaccharide; ICAM-1, intercellular adhesion molecule-1; PECAM-1, platelet endothelial cell molecule-1; NEC, necrotizing enterocolitis; HIF, Hypoxia-inducible Factor; GI, gastrointestinal; ER, endoplasmic reticulum.

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.