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ABSTRACT
The epidermis of the skin provides a barrier between the organism and the external environment. It is constantly subjected to physical and chemical insults, and thus susceptible to wounding and to neoplastic transformation. Long-lasting epigenetic modifications in epidermal stem cells are now shown to link responses to skin injuries with cell priming for carcinoma development, through regulation of histone H2A ubiquitylation.
Acknowledgments
Research in the author’s laboratory is supported with funds from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.
Disclosure statement
No potential conflict of interest was reported by the author.
Additional information
Funding
The work was supported by the Canadian Institutes of Health Research [FRN 168844]; Natural Sciences and Engineering Research Council of Canada .