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Abstract
We have prepared a novel nanobiotherapeutic, Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase], which not only transports both oxygen and carbon dioxide but also a therapeutic antioxidant. Our previous study in a severe sustained 90 min hemorrhagic shock rat model shows that it has a hepatoprotective effect. We investigate its hepatoprotective effect further in this present report using an alcohol-damaged primary hepatocyte culture model. Results show that it significantly reduced ethanol-induced AST release, lipid peroxidation, and ROS production in rat primary hepatocytes culture. It also significantly enhanced the viability of ethanol-treated hepatocytes. Thus, the result shows that Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] also has some hepatoprotective effects against alcohol-induced injury in in vitro rat primary hepatocytes cell culture. This collaborate our previous observation of its hepatoprotective effect in a severe sustained 90-min hemorrhagic shock rat model.
Disclosure statement
This laboratory is not connected to any commercial organizations. The research support for the study reported here comes from the Canadian Blood Service/Canadian Institutes of Health Research joint program that requires the authors to state that: “The opinion expressed in this article is the opinions of the investigators of this paper and not necessary those of the Canadian Blood Service nor of the Canadian Government”.
Dr. Wenhua Jiang came to this laboratory as a China Scholarship Council Visiting Scholar from the Department of Histology and Embryology, Norman Bethune Medical College of Jilin University, Changchun 130021, Jilin Province, China.
