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Abstract
Inflammatory bowel disease (IBD) is an inflammatory disorder of the digestive tract reported to be primarily caused by oxidative stress. In this study, alginate encapsulated nanoceramic carriers were designed to deliver acid labile antioxidant enzyme catalase orally. Complete system was characterized for size, loading efficiency, in vitro antioxidant assay and in vitro release. The prepared nanoceramic system was found to be spherical with diameter of 925 ± 6.81 nm. The in vitro release data followed the Higuchi model in acidic buffer whereas in alkaline pH sustained and almost first order release of enzyme was observed up to 6 h.
Acknowledgements
Authors are thankful to School of Studies Physics, Pt. Ravishankar Shukla University Raipur for XRD studies; All India Institute of Medical Sciences, New Delhi for Transmission Electron Microscopy; Director, University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), India for providing all necessary facilities for carrying out this work.
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.
Funding information
The authors thank UGC-MRP41–748-2012, DST-FIST, and UGC-BSR F(0).7–341/2011 for financial assistance relating to this work.