Identified key genes related to carotid atheroma plaque from gene expression chip

Abstract

As one of the leading reason in morbidity and death in the world, atherosclerosis is usually associated with vessel stenosis, ulceration, and inflammatory cell infiltration. However, the formation mechanism of atheroma plaque is unknown. In this research, we have used bioinformatics tools to identify 118 differential expression genes from a GEO dataset. Besides, we also revealed KYNU as a crucial gene in atheroma plaque development.

Keywords:

• Carotid atheroma plaque
• bioinformation
• GEO dataset
• KYNU

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Funding

This work was supported by The National Natural Science Fund, [grant number 81370441].