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Original Articles

Comparison of simultaneous and sequential administration of fentanyl–propofol for surgical abortion: a randomized single-blinded controlled trial

, , , , &
Pages 1045-1050 | Received 02 Jul 2016, Accepted 17 Sep 2016, Published online: 06 Oct 2016
 

Abstract

Propofol lipid emulsion (PLE) is a nanosized sedative, and it is used with a combination of salted antalgic prodrug, fentanyl citrate (FC). To illustrate the synergistic effect of mixing, we compared the sedation/analgesia resulting from simultaneous and sequential administration in surgically induced abortion (No. ChiCTR-IPC-15006153). Simultaneous group showed lower bispectral index, blood pressure, and heart rate, when cannula was inserted into the uterus. It also showed less frequency of hypertension, sinus tachycardia, movement, pain at the injection site, and additional FC. Therefore, premixing of PLE and FC enhanced the sedation and analgesia; stabilized the hemodynamics; lessened the incidence of movement and injection pain; and reduced the requirement of drugs.

Disclosure statement

The authors have no conflicts of interest to declare.

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