The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

Abstract

The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance of mesenteric microvascular function were explored in a rat model of hemorrhagic shock (HS). Following controlled hemorrhage, rats were infused with equal volumes of either pPolyHb, hetastarch (HES), or red blood cell (RBC). The results showed that pPolyHb was superior to HES and RBC in restoring hemodynamic stability and reversing anaerobic metabolism. We observed a reduction in the diameter of mesenteric microvasculature after HS. Resuscitation with pPolyHb and RBC was able to restore the diameters of the venules and arterioles, whereas HES failed to restore the diameters during the observation period.

Keywords:

• Polymerized porcine hemoglobin
• hemorrhagic shock
• hemodynamic stability
• mesenteric microcirculation

Acknowledgements

We acknowledge with thanks the grants from National High-tech R&D Program (863 Program) (grant no. 2012AA021902); National Natural Science Foundation of China (grant no. 81102367); China Scholarship Council of the Ministry of Education; and Shaanxi Science and Technology Department (grant nos.2016SF-243, 2011KTCL03-23, and 2011K12-03-10). This work was also supported by the State Project for Essential Drug Research and Development (grant no. 2014ZX09102043004).

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

We acknowledge with thanks the grants from National High-tech R&D Program (863 Program) (grant no. 2012AA021902); National Natural Science Foundation of China (grant no. 81102367); China Scholarship Council of the Ministry of Education; and Shaanxi Science and Technology Department (grant nos.2016SF-243, 2011KTCL03-23, and 2011K12-03-10). This work was also supported by the State Project for Essential Drug Research and Development (grant no. 2014ZX09102043004).