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Abstract
Potential roles of RNA N6-methyladenosine (m6A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m6A regulators within prostate cancer related to genetic variation, alternative splicing (AS), tumour mutational burden (TMB) and TME. Unsupervised clustering and risk prediction model constructed by 24 m6A regulators could predict scores of TME and prostate cancer patients prognosis. T cells CD8 was the intersection of immune cells which are related to multiple biological processes, and the fraction of T cells CD8 strongly correlates with immune associated gene sets. m6A methylation modification and immune cells infiltration played a nonnegligible role in prostate cancer. Our study represents a step towards personalized immunotherapy for prostate cancer patients.
Acknowledgements
We would like to extend our sincere gratitude to our departmental chair for all their support.
Consent for publication: Consent to publish has been obtained from the participants.
Author contributions
Chen Shao designed this study, Huimin Sun and Jianzhong Zheng collected data, Yue Zhao and Huimin Sun analysised data, Yue Zhao wrote this manuscript. Chen Shao revised the manuscript. All authors read and approved the final manuscript.
Disclosure statement
The authors declare that they have no conflicts of interest.
Data availability statement
The dataset supporting the conclusions of this article is included within the article.