Advanced search
Publication Cover
Emerging Microbes & Infections Volume 11, 2022 - Issue 1
Submit an article Journal homepage
1,856
Views
2
CrossRef citations to date
0
Altmetric
Antimicrobial Agents

Triazole-resistant Aspergillus luchuensis, an industrially important black Aspergillus spp. used in fermentation in East Asia, isolated from the patient with invasive pulmonary aspergillosis in China

Qiqi Wanga Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, People’s Republic of China;c Research Center for Medical Mycology, Peking University, Beijing, People’s Republic of China;d Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, People’s Republic of ChinaView further author information
,
Yun Lie Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, People’s Republic of ChinaView further author information
,
Yanming Lif Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaView further author information
,
Nir Osherovg Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelView further author information
,
Gustavo H. Goldmanh Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, BrazilView further author information
,
Paul E. Verweiji Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands;j Radboudumc – CWZ Center of Expertise for Mycology, Nijmegen, NetherlandsView further author information
,
Bo Zhenge Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, People’s Republic of ChinaView further author information
,
Ruoyu Lia Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, People’s Republic of China;c Research Center for Medical Mycology, Peking University, Beijing, People’s Republic of China;d Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, People’s Republic of ChinaView further author information
,
Wei Chena Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, People’s Republic of China;c Research Center for Medical Mycology, Peking University, Beijing, People’s Republic of China;d Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, People’s Republic of ChinaView further author information
,
Tianyu Lianga Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, People’s Republic of China;c Research Center for Medical Mycology, Peking University, Beijing, People’s Republic of China;d Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, People’s Republic of ChinaView further author information
,
Zhe Wana Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, People’s Republic of China;c Research Center for Medical Mycology, Peking University, Beijing, People’s Republic of China;d Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, People’s Republic of ChinaView further author information
&
Wei Liua Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, People’s Republic of China;c Research Center for Medical Mycology, Peking University, Beijing, People’s Republic of China;d Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1435-1438 | Received 29 Mar 2022, Accepted 06 May 2022, Published online: 26 May 2022
 
Sample our Health and Social Care journals, sign in here to start your FREE access for 14 days

ABSTRACT

Aspergillus luchuensis, an industrially important member of Aspergillus species belonging to section Nigri used in fermentation in East Asia, was isolated from an immunocompromised patient with probable invasive pulmonary aspergillosis who failed voriconazole therapy in China. This isolate showed non-wild-type susceptibility to itraconazole, voriconazole, isavuconazole, and posaconazole. A G1378A mutation in cyp51A, resulting in the G441S amino acid substitution, which is the homolog to G448S conferring triazole-resistance in A. fumigatus, was detected in the A. luchuensis isolate.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by National Key Research and Development Program of China [2021YFC2300400] and National Natural Science Foundation of China [81861148028, 81971912].
Download PDF

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.