Cat scratch disease with generalized bone lesions in an immunocompetent child

Jing Wanga Department of Infectious Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaView further author information

Wenjuan Chena Department of Infectious Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaView further author information

Meng Wangb School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaView further author information

Qiang Mic Department of Hematology Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaView further author information

Lijun Boa Department of Infectious Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaView further author information

Congli Yuanb School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, People’s Republic of China;d Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
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Qing Caoa Department of Infectious Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
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ABSTRACT

A 9-year-old immunocompetent girl with prolonged fever for 1 month was suspected of having a malignancy because of generalized bone abnormalities identified by MRI. Histopathology of liver tissues indicated the diagnosis of cat-scratch disease (CSD). Results of NGS, immunofluorescence and immunochemical assay confirmed the causative agent was Bartonella henselae. Paediatricians should increase their awareness of CSD as a cause for bone lesions, except for malignancy.

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Funding

This work was supported by the Interdisciplinary Program of Shanghai Jiao Tong University (grant number ZH2018QNA28), and Shanghai Municipal Commission of Agriculture and Rural Affairs (22Z530101402), Natural Science Foundation of China (19Z103010124).

Cat scratch disease with generalized bone lesions in an immunocompetent child

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Cat scratch disease with generalized bone lesions in an immunocompetent child

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