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Abstract
For the first time, we have prepared electrospun polyvinyl pyrrolidine (PVP) nanofibers loaded with enrofloxacin (PVP-ENRNF) using electrospinning technique. The morphology and physico-chemical properties were characterized by employing Scanning Electron Microscopy (SEM) and Fourier Transform InfraRed (FTIR) spectroscopy, respectively. Morphology by SEM revealed fiber diameter ranging from 450-725 nm. FTIR spectroscopy indicated physical interaction between the polymer and drug. Release profiles of enrofloxacin (ENR) from PVP-ENRNFs were studied, which controlled/influenced by the pH of the release media. Cumulative drug release profiles of PVP-ENRNFs at pH 3.8 (71.96 %), 6.4 (62.34 %) and 7.4 (54.14 %) were comparatively better than release profiles of pure ENR. These nanofibers exhibited potent antibacterial activity on tested microbes. These PVP-ENRNFs can be efficiently used as potential materials for oral as well as local delivery of enrofloxacin for treating respiratory and wound infections.