Simultaneous Spectrophotometric Estimation of Triamterene and Xipamide in Pure Form and Pharmaceutical Formulation by Iso-absorptive Point Dependent Methods

Abstract

The present work represents a simple, accurate, selective and sensitive UV-spectro-photometric methods for simultaneous estimation of xipamide and triamterene in pure and combined dosage form. The proposed methods are based on presence of iso-absorptive point. These methods include absorbance subtraction, amplitude modulation, Q analysis and absorbance ratio method. The methods have been validated for linearity, accuracy and precision and found to be rapid, precise and economical.

Keywords:

• xipamide & triamterene
• absorbance subtraction
• amplitude modulation
• Q analysis
• absorbance ratio