Synthesis, Spectral Characterization and Antitubercular Study of Novel Quinoline Schiff Base and Its Metal Complexes

Abstract

Synthesis of novel Schiff base from 2-hydroxy-6-methylquinolin-3-carbaldehyde and 4-methyl-benzenesulfonohydrazide has been carried out in the present work. Also, the metal complexes of Cu(II), Ni(II), Co(II) and Cd(II) have been synthesized. Schiff base and metal complexes were characterized by various analytical techniques such as CHN analyzer, XRD, FT-IR, UV-Visible, ESR, ¹H NMR, ¹³C NMR, MASS and TGA. Very low value of molar conductance indicates non electrolytic nature of the complexes. The analytical data shows that the ratio of metal to ligand in Cu(II), Ni(II), Co(II) and Cd(II) complexes is 1:2. FT-IR spectral data suggest that the ligand behaves as a tridentate O, N, O donor system. Magnetic susceptibility measurements reveal the paramagnetic behavior of all the complexes except Cd-complex. Further, the Schiff base and the metal complexes were screened for their antimycobacterial activity against M. Bovis BCG and M. tuberculosis H37Ra strains. Compounds 7, 8a, 8c & 8d exhibit very promising results against M. Bovis BCG and MTB H37Ra strains. Among all, Cu-complex shows highest MIC (2.8) value.

Keywords:

• Schiff base
• ESI MS
• ESR
• antimycobacterial
• MIC