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Abstract
Curcuma longa Linn., commonly known as Turmeric, Indian saffron or Haldi belongs to family Zingiberaceae., is a perennial herb with simple and large leaves. Its tubers, rhizomes and oil have great importance. Melaleuca alternifolia commonly known as tea tree oil, belonging to the family myrtaceae, has been used as a botanical medicine in various forms over the centuries for its antibacterial activity. In this study a cream have been formulated using vanishing cream base incorporating Curcuma longa ethanol extract and tea tree oil in different ratio. The formulated creams were tested for their microbicidal activity against various skin pathogens viz. Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC25354), Staphylococcus epidermis (ATCC 12228), Propionibacterium acne (ATCC 6919), Candida albicans (ATCC 36232), Methicillin Resistant Staphylococcus aureus (MRSA) (Clinical isolate), Methicillin Susceptible Staphylococcus aureus (MSSA) (Clinical isolate). The formulated creams showed excellent microbicidal activity against all the pathogens used in the test.