![Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5934/TOC-Subject-Sample-2021-Environment-Agriculture.jpg"})
Abstract
The present study was undertaken to assess the cardioprotective effect of ethanolic extract of Cassia siamea Lamk. leaves on Doxorubicin induced cardiac myopathy in rats. Doxorubicin was administered to rats in six equal doses intraperitoneally over a period of two weeks (cumulative dose of 15 mg/Kg) for all the study groups except normal group. The pretreatment for one week with ethanolic extract of C. siamea Lamk. leaves was given to the respective groups to assess the cardioprotective activity. On the 22 nd day various parameters such as body weight, heart weight, heart/body weight ratio, ECG recording, Invasive BP determination, serum markers such as creatine kinase - MB (CK - MB), lactatedehydrogenase (LDH), SGOT and SGPT was estimated. The tissue antioxidant markers viz. catalase (CAT), superoxide dismutase (SOD) and extent of lipid peroxidation viz. malondialdehyde (MDA) was also estimated. The Histopathological study of heart was carried out to assess the cardioprotective activity of the extract on Doxorubicin induced cardiac toxicity. Doxorubicin cause increase in all the serum enzyme markers and also alters the normal ECG pattern and blood pressure, while the ethanolic extract of C. siamea Lamk. (EECS) leaves significantly reduced the elevated levels of the enzymes and restores the ECG and BP close to normal. The EECS also significantly increased the tissue antioxidant levels of CAT and SOD, while decrease the MDA level and also restores the Histopathological architecture of the heart near to normal when compared with the groups treated with Doxorubicin control.